By F. W. Spiers
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Extra resources for Radioisotopes in the Human Body. Physical and Biological Aspects
2) is an exponential relationship and the systems we shall 1 4 Q (a) (b) 1 0 0 KQ K,0, 4> FIG. 5. Compartment models: (a) single compartment, ( b ) two compartments without back-flow, ( c ) two compartments with back-flow. analyze consist of "exponential" compartments. There are limitations to this method of analysis which we shall consider later; not all organs and tissues in the body operate under the simplifying assumptions adopted. 3. A SINGLE-COMPARTMENT MODEL The simplest model to consider is that of an organ or compartment receiving a given activity of some radioisotope which is then lost by 42 RADIOISOTOPES IN THE HUMAN BODY metabolic turnover, without back-transference, to another compartment or excreted from the body, as in Fig.
E . J. Williams, Proc. Roy. Soc. (London) Ser. A, 130: 310 (1931). 19. L. Katz and A. S. Penfold, Rev. Mod. , 24 : 28 (1952). 20. A. T . Nelms, Energy Loss and Range of Electrons and Positrons, Natl. Bur. S. G o v t . Printing Office, Washington, D . C , 1958, Circular N o . 577. 21. H . E . , Charles C Thomas, Springfield, Illinois, 1961, p. 560. 22. G. J. Hine and G. L. , Radiation Dosimetry, Academic Press, New York, 1956, p. 801. 23. E. H . Quimby, S. Feitelberg, and S. Silver, Radioisotopes in Clinical Practice, Lea & Febiger, Philadelphia, Pennsylvania, 1958.
4, to regard the thyroid compartment as taking labeled iodide from an "exponential" blood compartment and losing it entirely in the form of thyroxine. At a later time, however, when most of the labeled iodide has been removed from the blood compartment (see Fig. 9), the content of labeled material in the blood is mainly in the form of organically bound iodine transferred from the thyroid. The return of labeled iodide to the thyroid is then small, and it is possible to use an approximate twocompartment analysis for the content of organically bound iodine in the blood.
Radioisotopes in the Human Body. Physical and Biological Aspects by F. W. Spiers