By Lene Jorgensen, Hanne Morck Nielson
Advances in biotechnology have supplied scientists with a growing number of biopharmaceuticals akin to novel peptide and protein medicines in addition to nucleic acid dependent medicinal drugs for gene treatment. despite the fact that, winning supply of those biopharmaceuticals is an enormous problem simply because their molecular houses bring about negative actual and chemical balance within the physique and restricted membrane permeability. consequently researchers are constructing more than a few new supply applied sciences and fabrics to let those new medicinal drugs to be brought intact to their goal websites.
Delivery applied sciences for Biopharmaceuticals describes options to beat the most limitations for profitable supply of healing peptides, proteins, and nucleic acid-based medicinal drugs or vaccines relating to the location of management and the objective website. the various ways defined are said in formulations in present scientific trials in addition to in advertised items. Contents comprise:
- challenges in supply of biopharmaceuticals
- novel formula methods for peptide and protein injectables
- non-viral chemical vectors and viral expertise for supply of nucleic acid established medicines
- immune reaction, adjuvants and supply structures for vaccines
- several examples of supply platforms for different biopharmaceuticals
- a severe review of supply applied sciences for biopharmaceuticals
Delivery applied sciences for Biopharmaceuticals is an important single-volume creation to the applied sciences utilized by researchers to make sure effective supply of this intriguing new type of substances. will probably be of price to researchers and scholars operating in drug supply, formula, biopharmaceuticals, medicinal chemistry, and new fabrics development.Content:
Chapter 1 demanding situations in supply of Biopharmaceuticals; the necessity for complicated supply structures (pages 1–8): Hanne Morck Nielsen and Lene Jorgensen
Chapter 2 Novel formula methods for Peptide and Protein Injectables (pages 9–28): Mingshi Yang and Sven Frokjaer
Chapter three Novel Non?Injectable formula methods of Peptides and Proteins (pages 29–67): Shirui Mao, Dongmei Cun and Yoshiaki Kawashima
Chapter four Chemical Vectors for supply of Nucleic Acid?Based medicines (pages 69–92): Elizabeth A. Vasievich and Leaf Huang
Chapter five Viral know-how for supply of Nucleic Acids (pages 93–112): Shervin Bahrami and Finn Skou Pedersen
Chapter 6 The Innate Immune Responses, Adjuvants and supply structures (pages 113–127): S. Moein Moghimi
Chapter 7 Lipid Nanoparticle?Based platforms for supply of Biomacromolecule Therapeutics (pages 129–148): Susana Martins, Domingos C. Ferreira and Eliana B. Souto
Chapter eight Dendrimers in supply of Biopharmaceuticals (pages 149–168): Chandan Thomas and Fakhrul Ahsan
Chapter nine amendment of Peptides and Proteins (pages 169–191): Susanne Hostrup, Kasper Huus and Henrik Parshad
Chapter 10 Nanocarriers for the supply of Peptides and Proteins (pages 193–205): Kenneth Lundstrom
Chapter eleven Polymer?Based supply structures for Oral supply of Peptides and Proteins (pages 207–226): Bruno Sarmento, Domingos Ferreira and Teofilo Vasconcelos
Chapter 12 complex Pulmonary supply of Peptides or Proteins utilizing Polymeric debris (pages 227–244): Yu Seok Youn, Kang Choon Lee, You Han Bae, Kun Na and Eun Seong Lee
Chapter thirteen Polymer Microparticles for Nucleic Acid supply (pages 245–267): Tim Pearce, Jared Hierman and Chun Wang
Chapter 14 Pulmonary supply of Small Interfering RNA for Novel Therapeutics (pages 269–289): Qing Ge, David Evans, John J. Xu, Harry H. Yang and Patrick Y. Lu
Chapter 15 Lipid?Based Formulations for siRNA supply (pages 291–304): Camilla Foged, Pieter Vader and Raymond M. Schiffelers
Chapter sixteen mobile Bioavailability of Peptide Nucleic Acids (PNAs) Conjugated to mobilephone Penetrating Peptides (pages 305–338): Takehiko Shiraishi and Peter E. Nielsen
Chapter 17 DEAE?dextran?MMA Graft Copolymer for Non?Viral supply of DNA (pages 339–355): Yasuhiko Onishi, Yuki Eshita and Masaaki Mizuno
Chapter 18 Liposomes in Adjuvant platforms for Parenteral supply of Vaccines (pages 357–376): Dennis Christensen, Karen Korsholm, Grith Kroyer wooden, Afzal Mohammed, Vincent Bramwell, Peter Andersen, Else Marie Agger and Yvonne Perrie
Chapter 19 Influenza Virosomes as supply structures for Antigens (pages 377–393): Mario Amacker, Stefan Moese, Andreas R. Kammer, Ari Helenius and Rinaldo Zurbriggen
Chapter 20 GRAZAX®: An Oromucosal Vaccine for Treating Grass Pollen hypersensitive reaction with Immunotherapy (pages 395–404): Annette Rommelmayer Lundegaard, Lise Lund and Jorgen Nedergaard Larsen
Chapter 21 supply applied sciences for Biopharmaceuticals: A severe overview (pages 405–412): Marco van de Weert
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Extra resources for Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines
Opin. , 12, 212–219. 101. M. N. (1996) Goserelin: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in benign gynaecological disorders. Drugs, 51, 319–346. 102. W. and Civitelli, K. (2001) Managing advanced prostate cancer with Viadur (leuprolide acetate implant). Urol. , 21, 385–388. 103. , Lindenberg, T. et al. (2000) An implant releasing the gonadotropin hormone-releasing hormone agonist histrelin maintains medical castration for up to 30 months in metastatic prostate cancer.
H. W. (2000) Effects of solvent selection and fabrication on the characteristics of biodegradable poly(lactide-co-glycolide) microspheres containing ovalbumin. Arch. Pharm. , 23, 385–390. 67. Y. et al. (2001) Preparation and characterization of hCG loaded polylactide or poly(lactide-co-glycolide) microspheres using a modified water-in-oil-in water (w/o/w) emulsion solvent evaporation technique. J. , 18, 247–260. 68. A. P. (1999) Recombinant human bone morphogenetic protein-2 binding and incorporation in PLGA microsphere delivery systems.
A. et al. (1998) Preparation and characterization of cocrystalline suspension of [LysB28, ProB29]-human insulin analogue. J. Pharm. , 87, 170–176. 48. , Barriocanal, L. and Lindholm, A. (1999) Comparative pharmacokinetics and pharmacodynamics of the novel rapid-acting insulin analogue, insulin aspart, in healthy volunteers. Eur. J. Clin. , 55, 199–203. 49. P. et al. (2005) Study of etanercept, a tumor necrosis factor-alpha inhibitor, in recurrent ovarian cancer. J. Clin. , 23, 5950–5959. 50. , Borvak, J.
Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines by Lene Jorgensen, Hanne Morck Nielson