By Urban Gullberg, Gösta Bergh, Mats Ehinger (auth.), Razelle Kurzrock M.D., Moshe Talpaz M.D. (eds.)
Over the decade, cytokine examine has emerged as the most interesting and important fields for delivering primary wisdom of standard and irregular human improvement. at the present time, it truly is obvious that cytokines orchestrate development from the early embryonic level to adulthood and are answerable for the traditional functionality of almost each organ procedure. in addition, almost all affliction states were linked, at the least partly, with cytokine aberrations.
during this quantity, the editors have introduced jointly the world over recognized specialists within the box of interleukin learn to supply a finished overview of the biology of the interleukins and their position in either overall healthiness and sickness, whereas retaining a stability among the elemental technology and scientific facets. Cytokines: Interleukins and theirReceptors could be of curiosity to a large choice of researchers together with scientific hematologists, oncologists, immunologists, as well as scientific and PhD scholars and researchers with an curiosity in cytokines.
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Additional info for Cytokines: Interleukins and Their Receptors
Banner DW, D'Arcy A, lanes W, Gentz R. Schoenfeld H-J, Broger C, Loetscher H, Lesslauer W. Crystal structure of the soluble human 55 kd receptor-human TNF beta complex: Implications for TNF receptor actovation. Cell 73:431-445,1993. 110. Hoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S-I, Sameshima M, Hase A, Seto Y, Nagata S. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66:233-243, 1991. 111. Inui S, Kaisho T, Kikutani H, Stamenkovic I, Seed B, Clark EA, Kishimoto T.
BFGF stimulates adherent stromal cells in human long-term bonemarrow cultures, thereby promoting hematopoietic cell development [71,72]. bFGF is deposited in a complex with heparan sulfate proteoglycans within the ECM and is also found on the cell surface of stromal cells [71,72]. bFGF appears to affect human megakaryocytopoiesis by directly promoting progenitor cell proliferation, as well as stimulating marrow accessory cells to release an unknown megakaryocyte growth factor(s) . Thus, bFGF is probably a component of megakaryocyte microenvironment that may play an important role in the control of human megakaryocytopoiesis.
It contains both GAT A and the ets sequences in its 5'-untranslated region; mutations in both regions markedly decrease promotor activity without altering tissue expression, suggesting that tissue specificity is controlled elsewhere . Corroborating this possibility, 2 other control regions in the 5' -un translated region of lIb gene interact with proteins present only in megakaryocytes, and deletion of these domains significantly decrease lIb promotor activity . Thus, other proteins are involved in transcriptional control of megakaryocytes-specific genes, and multiple transcription factors may be required for full differentiation.
Cytokines: Interleukins and Their Receptors by Urban Gullberg, Gösta Bergh, Mats Ehinger (auth.), Razelle Kurzrock M.D., Moshe Talpaz M.D. (eds.)