Download e-book for kindle: Cyclopropane Derived Reactive Intermediates (1990) by G. Boche, H. M. Walborsky, Saul Patai, Zvi Rappoport

By G. Boche, H. M. Walborsky, Saul Patai, Zvi Rappoport

ISBN-10: 0470772409

ISBN-13: 9780470772409

ISBN-10: 0471927481

ISBN-13: 9780471927488

This replace quantity within the Chemistry of useful teams sequence presents concise but accomplished insurance of contemporary advancements within the chemistry of the cyclopropyl crew of compounds, reactive intermediates specifically. The specialists who contributed the chapters on cyclopropyl cations and cation radicals within the unique major quantity (published in 1987) have further new fabric at the topic and feature up-to-date their unique paintings on anions and anion radicals.

Content:
Chapter 1 Cyclopropyl radicals, anion radicals and anions (pages 1–108):
Chapter 2 Appendix to ‘Cyclopropyl radicals, anion radicals and anions’ (pages 109–116):
Chapter three Cyclopropyl cations (pages 117–173):
Chapter four Cyclopropyl carbenoids (pages 175–205):
Chapter five Cyclopropane cation radicals (pages 207–236):

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Extra info for Cyclopropane Derived Reactive Intermediates (1990)

Sample text

SCE yielded the hydrocarbon pheMe HI Ph Br M *ehpPh ( - )-(R)-l-methyl-2,2-diphenylcyclopropane (49)with an optical purity of 25 %. 98 electrons per molecule reacted. The reduction involves two single electron transfers (SET). 40 Cyclopropane derived reactive intermediates The reduction is viewed as occurring in the following manner'". (1) RBr+e- +[R-Br]' (2)[R-Br]' + R'+ Br(3) R'+e- + R (4)R'+ Hg" + RHgb (5) RH&+e-+R-+Hg" (6)R H L + RHgi + RHg,,-R + RHgR (7)R H g R + e - + R - + R H g ' y (8) R(9) R- + H&- RHgi + CHSCN + R-H + -CH,CN + Et,N+Br- +R-H + CH,=CH, + Et,N + Br- As in direct metalation, the reaction occurs at the metal surface.

Where n = 2, 4, or 6. The aggregates have been shown to be stable at 0°C for at least 1 h and are viewed as molecular species which exist in a solvent cage of THF. Upon thermolysis a homolytic cleavage of two R'S)-C~ bonds occur (R = l-methyl-2,2-diphenylcyclopropyl and superscript (S)or (R) relates to configuration) with the formation of Cu" and the concomitant coupling within the solvent cage (reaction a), of RCS) to yield (+)-( RcR), R(9-97 with retention ofconfiguration. If within thecageoneof the RIS) rotates 180", this would lead to the formation of RIR!

65 C(1) 63 15 4 5 I0 62 'CF, 6' 39 I 46 1. Cyclopropyl radicals, anion radicals and anions 23 TABLE 13. Continued. Entry Structure % Favared Method' Ref. Br 1 Ob 67 1 lb 51 12b 51 '~31 50 14 17 94,loo C(2) 16 94,loo C(2) 76 95 C(2) 76 80 76 24 Cyclopropane derived reactive intermediates TABLE 13. Entry Continued. Structure % Favored Method' Ref. 76 87 19 76 \ 39,17 78 a Rapidly ramngca to the cyclobutenyl radical. This radical may well be a it radical. Rcault in toluene; opposite stcrcochemistry in diisopropylbenzcne.

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Cyclopropane Derived Reactive Intermediates (1990) by G. Boche, H. M. Walborsky, Saul Patai, Zvi Rappoport


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