By Valerian E. Kagan, Peter J. Quinn
Considering its discovery in 1957, Coenzyme Q has piqued the curiosity of scientists from a variety of disciplines as a result of its bioenergetics, vitamin-like habit, and interactions with antioxidant supplements E and C. Coenzyme Q: Molecular Mechanisms in future health and disorder is a complete treatise in this often-studied coenzyme. foreign specialists conceal the study that ended in its emergence as a thrilling, new nutritional supplement.The current quantity summarizes the newest advancements in numerous components of CoQ examine. New recommendations on extramitochondrial capabilities of CoQ are mentioned in chapters, whereas fresh discoveries in biosynthetic pathways for CoQ in response to molecular genetic techniques are offered in one other chapter.Further chapters discover the position of CoQ as an antioxidant, revealing the necessity for extra study during this intriguing region. This booklet may be of maximum curiosity to biochemists, biophysicists, molecular and telephone biologists, in addition to nutritionists and biomedical medical experts.
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Extra info for Coenzyme Q: Molecular Mechanisms in Health and Disease
C to freely diffuse, and local pools of cyt. c oscillating between closely packed enzymes may be responsible for electron transfer. 3 CONCLUSIONS ON THE MECHANISMS OF ELECTRON TRANSFER CONTROL Mobility of the electron transfer components in the mitochondrial respiratory chain represents the main prerequisite for electron flux. A large body of experimental data in isolated mitochondrial membranes demonstrated that ubiquinone and cytochrome c may be used during electron transfer as substrate-like mobile components.
Bioenergetics of Membranes, Packer, Papageorgiou & Trebst, Elsevier, Amsterdam, 1977, 189. 57. Stidham, M. , McIntosh, T. , and Siedow, J. , On the localization of ubiquinone in phosphatidylcholine bilayers, Biochim. Biophys. Acta, 767, 423, 1984. 58. , 426, 77, 1998. 59. , Genova, M. , Localization and mobility of Coenzyme Q in lipid bilayers and membranes, BioFactors 9, 87, 1999. 60. , EPR, ENDOR and TRIPLE resonance and MO studies on ubiquinones (Q-n): comparison of radical anions and cations of coenzymes Q-10 and Q6 with the model compounds Q-2 and Q-0, Acta Chem.
This effect is not observed when coenzyme Q is solvated by dodecane.
Coenzyme Q: Molecular Mechanisms in Health and Disease by Valerian E. Kagan, Peter J. Quinn