By David S. Goodsell
Discussions of the elemental structural, nanotechnology, and process engineering rules, in addition to an introductory assessment of crucial ideas and strategies in biotechnology, might be incorporated. textual content is gifted side-by-side with vast use of high quality illustrations ready utilizing leading edge special effects strategies. comprises quite a few examples, such purposes in genetic engineering. Represents the one to be had advent and review of this interdisciplinary box, merging the actual and organic sciences. Concludes with the authors' specialist overview of the longer term promise of nanotechnology, from molecular "tinkertoys" to nanomedicine.?? David Goodsell is writer of 2 alternate books, equipment of lifestyles and Our Molecular Nature, and Arthur Olson is the world's chief in molecular pictures and nano-scale illustration.
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Extra info for Bionanotechnology: Lessons from Nature
ISBN: 0-471-41719-X 43 44 Biomolecular Design and Biotechnology powerful tools for designing bionanomachines are available to anyone with a computer and imagination, and effective tools for producing these custom bionanomachines are accessible to any moderately-sized biotech start-up company. Current methods of biotechnology excel at modification. This is a powerful capability that leverages the extensive body of working nanomachinery that is available from natural sources. We can introduce specific changes into the plans for a given protein, or we can splice together the plans for several different proteins, creating a hybrid molecule with combined function.
Once a key piece of machinery is perfected and placed in use, it is difficult to replace it or make major modifications without killing the cell. This is particularly true of central molecular processes like the reading and use of genetic information, the production of energy, and reproduction, all of which require the concerted effort of dozens of complex molecular machines. This leads to a remarkable uniformity in all earthly living things when observed at the molecular level. All are built of the same basic components, discovered once by evolution and used in all subsequent organisms.
Using these modified plans, we can then engineer bacteria to produce large quantities of the mutant or chimeric protein. Thousands of academic and industrial laboratories are using these methods for medicine, bioremediation, and countless other applications. And several exciting new techniques based on biological evolution, described in Chapter 6, allow thousands of modifications to be tested simultaneously, greatly speeding the discovery of biomolecules with new functions. Design of entirely new bionanomachines, on the other hand, is currently more difficult than modification of natural bionanomachines.
Bionanotechnology: Lessons from Nature by David S. Goodsell