By Noboru Motohashi
Heterocyclic chemistry is the most important department of chemistry overlaying two-thirds of the chemical literature and this publication covers the new subject matters of frontier examine summarized by way of reputed scientists within the field.
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Extra resources for Bioactive Heterocycles VI: Flavonoids and Anthocyanins in Plants, and Latest Bioactive Heterocycles I
Similarly, Coriandrum sativum (coriander) has also been used as a traditional treatment of diabetes. The coriander incorporated into the diet and drinking water could reduce the hyperglycaemia of the streptozotocindiabetic mice. 7-fold) of the isolated murine abdominal muscle, more efﬁciently than insulin. 7-fold stimulation of insulin secretion from a clonal B-cell line. This effect was abolished by diazoxide, and the prior exposure to the extract did not alter the subsequent stimulation of insulin secretion by l-alanine, therefore negating an effect due to the detrimental cell damage.
The therapeutic efﬁcacy of the treatment on swelling, itching, heaviness and pain was evaluated. Positive clinical responses such as improved or absent symptoms were observed in over 80% of patients, including signiﬁcant improvement of symptoms after the ﬁrst 10 days of treatment. The oligomeric proanthocyanidins might be responsible for the rapid reduction of the swelling of the lower limbs and also correlated with the other evaluative symptoms such as heaviness and itching. The most striking responses were observed for itching and pain, however, which completely disappeared during the course of therapy in 80% (for itching) and 53% (for pain) of the patients, respectively.
The DNA-migration was calculated as Olive tail moment (OTM). Catechin and a low-molecular weight proanthocyandin fraction only slightly increased the OTM up to 166 µg/mL, whereas hamamelitannin and the proanthocyanidin fraction with higher molecular weight led to a twofold enhancement of OTM at the same concentrations. These effects were dose-independent. 5 µg/mL) led to a signiﬁcant reduction in the induced DNA damage. The inhibitory effects of proanthocyanidins were stronger than those of catechin and hamamelitannin; the lowest effective concentrations were about 2 µg/mL.
Bioactive Heterocycles VI: Flavonoids and Anthocyanins in Plants, and Latest Bioactive Heterocycles I by Noboru Motohashi