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By Clemens Lamberth, J?rgen Dinges

ISBN-10: 3527339477

ISBN-13: 9783527339471

ISBN-10: 3527693939

ISBN-13: 9783527693931

ISBN-10: 3527693947

ISBN-13: 9783527693948

ISBN-10: 3527693955

ISBN-13: 9783527693955

ISBN-10: 3527693963

ISBN-13: 9783527693962

Following the profitable and confirmed inspiration utilized in "Bioactive Heterocyclic Compound sessions" by way of an analogous editors, this e-book is the 1st to give licensed pharmaceutical and agrochemical compounds labeled by means of their carboxylic acid performance in a single convenient volume.
all the round forty chapters describes one or general syntheses of a selected compound type and offers concise details at the heritage of improvement, mode of motion, organic job and box of software, in addition to structure-activity relationships. furthermore, similarities and variations among prescription drugs and agrochemicals are mentioned within the creation.
Written through a workforce of specialists within the box, it is a priceless reference for researchers in academia and chemical or pharmaceutical businesses operating within the box of overall synthesis and typical product chemistry, drug improvement, and crop safety study

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25, 1960. J. S. (1997) Optical resolution of methylphenidate using O, O′ -bisaroyl tartaric acids (Medeva Europ). Patent WO9727176, July 31, 1997. Prashad, M. and Hu, B. (2000) Process for preparing the d-threo isomer of methylphenidate hydrochloride (Novartis). Patent US6162919, Dec. 19, 2000. , and Giannousis, P. (1999) Tetrahedron: Asymmetry, 10, 3111–3116. Prashad, M. and Har, D. (2000) Process for preparing the d-threo isomer of methylphenidate hydrochloride (Novartis). Patent US6100401, Aug.

29, 2290–2297. 37. J. (1991) J. Med. , 34, 2202–2208. 38. , and Poet, R. (1948) J. Pharm. Exp. , 94, 359–366. 39. , and Strichartz, G. (1985) J. Pharm. Exp. , 237, 773–781. 39 Part II Cardiovascular Diseases Bioactive Carboxylic Compound Classes: Pharmaceuticals and Agrochemicals, First Edition. Edited by Clemens Lamberth and Jürgen Dinges. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA. Published 2016 by Wiley-VCH Verlag GmbH & Co. KGaA. 1 Introduction The fibrates are a class of carboxylic acid derivatives that have been used in the treatment of hyperlipidemia since the 1960s.

It was speculated that this could be due to steric effects [52]. Deutsch, however, reported that the N-Bn analog demonstrated improved binding to DAT relative to (±)-threo-3 [53]. Converting the piperidine ring to a morpholine, decreasing the size of the ring to the pyrrolidine, or increasing it to the azepane or azocane resulted in a significant loss of DAT binding activity. Interestingly, Davies reported that pyrrolidine analogs of (±)-threo-3 that contained the 2-naphthyl group in place of the phenyl ring displayed high binding affinity and selectivity for SERT [54].

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Bioactive carboxylic compound classes: pharmaceuticals and agrochemicals by Clemens Lamberth, J?rgen Dinges


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