Download e-book for kindle: Antiandrogens in Prostate Cancer: A Key to Tailored by Louis Denis (auth.), Professor Dr. Louis Denis (eds.)

By Louis Denis (auth.), Professor Dr. Louis Denis (eds.)

ISBN-10: 3642457452

ISBN-13: 9783642457456

ISBN-10: 3642457479

ISBN-13: 9783642457470

The creation of maximal androgen blockade as a medical treatment by way of Brachi and Labrie greater than a decade in the past resulted in an enormous controversy at the scientific use of antiandrogens within the therapy of prostate melanoma. 3 consensus conferences have been to that end prepared with the help of the yankee melanoma Society, the Urological staff of the eu association for learn and therapy of melanoma and the overseas Prostate overall healthiness Council. the 1st result of the meta-analysis of twenty-two trials didn't positioned an finish to the debate, even if, and clinicians have been left burdened via conflicting reviews released via dozens of specialists. The assembly in the back of the current quantity created a discussion board for the scientists who constructed the medicine and expert clinicians to provide a consensus. the result's an outline of the sphere, condensed from countless numbers of courses. the data has been up to date to supply certain scientific symptoms for using antiandrogens together remedies and monotherapy for the person sufferer. we are hoping that this workforce attempt will facilitate ongoing discussions and bring about greater sufferer care in addition to elevated wisdom of the medication which are so very important to our sufferers' caliber of existence and survival.

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4. Prostate of castrated dogs A After 6 months of treatment with 3,17B-androstanediol (25 mg weekly) B After 6 months of treatment with 3,17B-androstanediol (25 mg weekly) plus cyproterone acetate (600 mg weekly) Magnification: approx. x 800. Staining: Acid phosphatase Pharmacology of Cyproterone Acetate 37 '-';. % inhibition of prostate weight 100 CPA. •....... •••••• .. ' . _. //. ,i/,'''~ ~~ ~~ ~~~ ~ ____ - -- --- --- - -- -' FL, 50 3 mg ,,;f " : I I Fig. 5. Long-term effects of the anti androgens cyproterone acetate (CPA) and flutamide (FL) on prostate weight in adult intact male rats I I I I O+-~----r-----~------------~--~ 3 6 12 weeks Antiandrogenic Potency of CPA and Flutamide CPA in Combination with LHRH Agonists in the Initial Phase of Use Pure antiandrogens (flutamide has been tested) are relatively more effective in castrated and androgen replaced animals than CPA.

Growth of terminal hair is inhibited by CPA. Symptoms of androgenisation (acne, seborrhoea, hirsutism, androgenic alopecia) are among the most important indications for CPA. 40 F. Neumann Progestational and Antigonadotrophic Activity of CPA The progestational potency of CPA is important for its clinical use in both women and nonorchidectomised men. CPA has been shown in classic tests to be a potent progestogen. It is one of the most effective progestogens of the group of hydroxyprogesterone derivatives [3] and has about the same range of effects as progesterone.

CPA does not accumulate. An equilibrium between administration and excretion is established after 8 to 10 days' use. With a half-life of almost 2 days a highly constant concentration is achieved in target tissues for androgens (and antiandrogens). The administration of the depot (300 mg/ampoule) leads after 2 to 3 days to maximal substance levels of about 300 to 400 ng/ml with a half-life of 4 days. An equilibrium is established after 4 injections (7-day intervals) at the latest. Pharmacology The pharmacology of CPA has been described in at least 150 articles and several book chapters by our group [for reviews see 13-19], and at least 300 to 500 articles have been published by other authors; in the latter CPA was used mainly as a tool in basic research.

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Antiandrogens in Prostate Cancer: A Key to Tailored Endocrine Treatment by Louis Denis (auth.), Professor Dr. Louis Denis (eds.)


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