Download PDF by Giovanni Luca Beretta, Franco Zunino (auth.), Karsten Krohn: Anthracycline Chemistry and Biology II: Mode of Action,

By Giovanni Luca Beretta, Franco Zunino (auth.), Karsten Krohn (eds.)

ISBN-10: 3540758127

ISBN-13: 9783540758129

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Abstract The clinical use of doxorubicin and other quinone-hydroquinone anticancer anthracyclines is limited by a dose-related cardiotoxicity. Here, we review the correlation of cardiotoxicity of doxorubicin with its peak plasma concentration and diffusion in the heart, followed by reductive bioactivation or oxidative inactivation. One-electron quinone reduction and two-electron side chain carbonyl reduction are accompanied by iron and free radical reactions that are responsible for many aspects of anthracycline cardiotoxicity.

Batist G (2007) Cardiovasc Toxicol 7:72 15. Cortes J, Estey E, O’Brien S, Giles F, Shen Y, Koller C, Beran M, Thomas D, Keating M, Kantarjian H (2001) Cancer 92:7 16. Fassas A, Buffels R, Anagnostopoulos A, Gacos E, Vadikolia C, Haloudis P, Kaloyannidis P (2002) Br J Haematol 116:308 42 P. Menna et al. 17. O’Byrne KJ, Thomas AL, Sharma RA, DeCatris M, Shields F, Beare S, Steward WP (2002) Br J Cancer 87:15 18. Jeyaseelan R, Poizat C, Wu HY, Kedes L (1997) J Biol Chem 272:5828 19. Arai M, Tomaru K, Takizawa T, Sekiguchi K, Yokoyama T, Suzuki T, Nagai R (1998) J Mol Cell Cardiol 30:243 20.

36 36 38 References . . . . . . . . . . . . . . . . . . . . 41 . . . . . . . . . . . . . . . . . . Abstract The clinical use of doxorubicin and other quinone-hydroquinone anticancer anthracyclines is limited by a dose-related cardiotoxicity. Here, we review the correlation of cardiotoxicity of doxorubicin with its peak plasma concentration and diffusion in the heart, followed by reductive bioactivation or oxidative inactivation.

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Anthracycline Chemistry and Biology II: Mode of Action, Clinical Aspects and New Drugs by Giovanni Luca Beretta, Franco Zunino (auth.), Karsten Krohn (eds.)


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